Journal
DNA REPAIR
Volume 2, Issue 5, Pages 629-638Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1568-7864(03)00037-5
Keywords
photoreactivation; photoproducts; placental mammals
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Kelner and Dulbecco first reported in the 1940s and 1950s the reversal of ultraviolet damage in bacteria and phage by illumination with visible light. The first publications, reprinted here, represented the discovery of a widespread repair mechanism that was named photoreactivation (PHR), that directly reversed photoproducts to their individual pyrimidine components. Between them, these pioneers demonstrated that photoreactivation had a cellular basis, could be defined by wavelength optima indicating specific molecular photoreceptors, and had a widespread phyletic distribution except for its absence from placental mammals. (C) 2003 Elsevier Science B.V. All rights reserved.
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