Synthesis, structure and antibacterial activities of novel ferrocenyl-containing 1-phenyl-3-ferrocenyl-4-triazolyl-5-aryl-dihydropyrazole derivatives

A series of substituted ferrocene-containing propenones have been prepared from acetylferrocene. Subsequently, condensation-of these propenones with phenylhydrazme gave desired dihydropyrazole derivatives, which structures have been characterized by spectra data and crystal X-ray diffraction analysis. Their antibacterial activities were screened. The mechanism involving 1,4-addition of phenylhydrazine to-these propenones by initial reaction at N-1 to give dihydropyrazole derives and by initial reaction at N-2 to give an intermediate has also been discussed. (C) 2003 Elsevier Science B.V. All rights reserved.