Journal
ORGANIC LETTERS
Volume 5, Issue 10, Pages 1685-1688Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol034333n
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- NCI NIH HHS [CA27489] Funding Source: Medline
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[GRAPHICS] (L)-Proline catalyzed the enzyme-like direct asymmetric assembly of aldehydes, ketones, and azodicarboxylic acid esters to provide optically active beta-amino alcohols. This assembly reaction uses both aldehydes and ketones as donors in one pot. The aldol-derived stereocenter is formed with a reduced facial selectivity in reactions involving (R)-amino aldehydes. The reactions can be performed on a multigram scale under operationally simple and safe conditions without the requirement of an inert atmosphere or dry solvents.
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