Journal
NATURE
Volume 423, Issue 6937, Pages 316-318Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature01654
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For a long time, the skeleton was seen as an amorphous tissue of little biological interest. But such a view ignored the large number of genetic and degenerative diseases affecting this organ. Over the past 15 years, molecular and genetic studies have modified our understanding of skeletal biology. By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities.
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