Journal
ORGANIC LETTERS
Volume 5, Issue 10, Pages 1629-1632Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol034231x
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Funding
- NIGMS NIH HHS [T32-GM08362] Funding Source: Medline
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[GRAPHICS] Presented here is a metabolically engineered yeast strain that produces sesquiterpenes. Epi-cedrol synthase expressed in a native yeast strain converted endogenous farnesyl pyrophosphate to 90 mug/L epi-cedrol. This system was genetically modified to increase foreign terpene yields to 370 mug/L. The best yields were obtained by overexpressing a truncated 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in a upc2-1 mating type a background. This system allows sufficient production to characterize novel sesquiterpene synthase genes.
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