Journal
GENES & DEVELOPMENT
Volume 17, Issue 10, Pages 1271-1280Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1087303
Keywords
MAP kinase; JNK; bone morphogenetic protein-4; sonic hedgehog; Pax2; coloboma
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The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein kinases is stimulated in response to a wide array of cellular stresses and proinflammatory cytokines. Mice lacking individual members of the Ink family (Jnk1, Jnk2, and Jnk3) are viable and survive without overt structural abnormalities. Here we show that mice with a compound deficiency in Ink expression can survive to birth, but fail to close the optic fissure (retinal coloboma). We demonstrate that INK initiates a cytokine cascade of bone morphogenetic protein-4 (BMP4) and sonic hedgehog (Shh) that induces the expression of the paired-like homeobox transcription factor Pax2 and closure of the optic fissure. Interestingly, the role of INK to regulate BMP4 expression during optic fissure closure is conserved in Drosophila during dorsal closure, a related morphogenetic process that requires INK-regulated expression of the BMP4 ortholog Decapentaplegic (Dpp).
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