Journal
GENES & DEVELOPMENT
Volume 17, Issue 10, Pages 1219-1224Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1076103
Keywords
beta-catenin; hair follicle; transgenic mouse; anagen; hair cycle
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Funding
- NCI NIH HHS [CA46592, CA87837, R01 CA087837, P30 CA046592, R01 CA085463, CA85463] Funding Source: Medline
- NIAMS NIH HHS [R01 AR045973] Funding Source: Medline
- NIGMS NIH HHS [T32GM07863, T32 GM007863] Funding Source: Medline
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Writs have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of beta-catenin in the skin. Chronic activation of beta-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of beta-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition.
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