Journal
FEMS MICROBIOLOGY LETTERS
Volume 222, Issue 1, Pages 137-141Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0378-1097(03)00255-6
Keywords
genetic regulation; toxin gene; two-component system; genome; plasmid; Clostridium perfringens
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We analyzed the transcriptional regulation of the putative virulence genes encoded on the plasmid pCP13 from Clostridium perfringens strain 13. The transcription of the beta2-toxin (cpb2) and possible collagen adhesin (cna) genes were regulated in both a positive and negative manner, respectively, by the two-component VirR/VirS system. The secondary regulator of the VirR/VirS system, VR-RNA, also affects the expression of both of these genes in the same fashion as the VirRN/VirS system. This indicates that the global regulatory cascade of the VirR/VirS system controls the expression of virulence genes located on the plasmid, as well as those found chromosomally in C. perfringens strain 13. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Microbiological Societies.
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