Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 10, Pages 4067-4070Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo020690k
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High-throughput screening considering a library of 96 chiral P-ligands involved in two types of Rh-I complexes was used for the identification of homogeneous catalysts for the highly enantioselective reductive amination of a-keto acids with benzylamine. After optimization of the reaction conditions and scale-up with a cationic Rh-Deguphos catalyst, a range of chiral alpha-amino acids could be produced by this new reaction in good yield and by up to 98% ee.
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