4.4 Article

A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 21, Pages 4129-4131

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00813-X

Keywords

TMSI; Hantzsch 1,4-dihydropyridines; one-pot condensation; ambient temperature

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The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature in the presence of iodotrimethylsilane (TMSI) generated in situ in CH3CN. in excellent yields. (C) 2003 Elsevier Science Ltd. All rights reserved.

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