Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 34, Issue 3, Pages 479-486Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.113.302737
Keywords
atherosclerosis; lipid phosphate phosphatase; lysophosphatidic acid
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Funding
- Heart Lung and Blood Institute [R01HL078663]
- National Center for Research Resources [P20RR021954]
- National Institute of General Medical Sciences [P20GM103527]
- National Center for Research Resources
- National Center for Advancing Translational Sciences, National Institutes of Health (NIH) [UL1TR000117, TL1TR000115]
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The structurally simple glycero- and sphingo-phospholipids, lysophosphatidic acid (LPA) and sphingosine-1-phosphate, serve as important receptor-active mediators that influence blood and vascular cell function and are positioned to influence the events that contribute to the progression and complications of atherosclerosis. Growing evidence from preclinical animal models has implicated LPA, LPA receptors, and key enzymes involved in LPA metabolism in pathophysiologic events that may underlie atherosclerotic vascular disease. These observations are supported by genetic analysis in humans implicating a lipid phosphate phosphatase as a novel risk factor for coronary artery disease. In this review, we summarize current understanding of LPA production, metabolism, and signaling as may be relevant for atherosclerotic and other vascular disease.
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