Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori

VacA is a major virulence factor of the widespread stomach-dwelling bacterium Helicobacter pylori. It causes cell vacuolation and tissue damage by forming anion-selective, urea-permeable channels in plasma and endosomal membranes. We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA. Red wine and green tea, which contain many of the compounds in question, also potently inhibit the toxin. These observations suggest that polyphenols or poly-phenol derivatives may be useful in the prevention or cure of H. pylori-associated gastric diseases. (C) 2003 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.