Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 36, Issue 3, Pages 199-205Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0928-8244(03)00091-9
Keywords
Helicobacter; lipoprotein; intranasal immunization; mouse; guinea pig
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Mice and guinea Pigs were intranasally immunized with either recombinant lipoprotein 20 or Helicobacter pylori outer membrane vesicles (OMV). Cholera toxin was used as mucosal adjuvant. In mice, both vaccines elicited systemic and local IgG responses, which correlated with significantly lower levels of H. pylori colonization. In contrast, only OMV proved immunogenic in guinea pigs, with the development of both systemic and local immune responses. These antibodies did not, however, correlate with protection in these animals, which suggests that vaccine formulation is as important as choice of antigen in the development of an H. pylori vaccine. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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