InBr3-Et3N promoted alkynylation of aldehydes and N,O-acetals under mild conditions:: facile and simple preparation of propargylic alcohols and amines

The use of a novel InBr3-Et3N reagent system to promote addition reactions of 1-alkynes not only with a variety of aromatic or bulky aliphatic aldehydes but also with N,O-acetals is described. The corresponding propargylic alcohols or amines are produced in good to excellent yields. (C) 2003 Elsevier Science Ltd. All rights reserved.