4.4 Article

Neoglycoconjugates, part 4.: New types of glycoconjugates:: O-glycosylated, N-glycosylated and O-,N-diglycosylated isoserine derivatives

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 22, Pages 4223-4226

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)00896-7

Keywords

hexafluoroacetone; (S)-isoserine; beta-amino acids; glycosylation; peptide modification

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Starting from hexafluoroacetone-protected malic acid O-glycosylated, N-glycosylated and O-,N-diglycosylated (S)-iso-serine derivatives have been synthesized. The new compounds represent glycosylated beta-alanine surrogates, i.a. suitable for beta-peptide modification. (C) 2003 Elsevier Science Ltd. All rights reserved.

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