Journal
SCIENCE
Volume 300, Issue 5624, Pages 1439-1443Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1083516
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- NIGMS NIH HHS [GM61603] Funding Source: Medline
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In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25 selenoproteins.
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