Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 470, Issue 1-2, Pages 33-36Publisher
ELSEVIER
DOI: 10.1016/S0014-2999(03)01787-4
Keywords
alcohol; self-administration; NR2B subunit; protein; up-regulation
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Forced ethanol drinking for several days and application of ethanol to cell cultures changes expression levels of various NMDA receptor subunits in rodents. We investigated the influence of long-term voluntary ethanol consumption of moderate ethanol doses on polypeptide levels of the NMDA receptor subunit 2B (NR2B) in various forebrain regions of rats and found a mild increase selectively in the frontal cortex. This result is in accordance with and extends findings from studies using high doses of ethanol for a short period and suggests that the NR2B might be a potential target for an effective treatment of alcoholic patients. (C) 2003 Elsevier Science B.V. All rights reserved.
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