Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 33, Issue 2, Pages 170-177Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.112.300068
Keywords
immune response; macrophage polarization; microRNA
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Funding
- National Institutes of Health [HL105473, HL097218, HL076206]
- American Heart Association [10SDG4210009]
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Inflammation is essential to combat invading microbial pathogens. In this process, the involvement of multiple immune cell populations is crucial in mounting an optimum immune response. In the past decade, a new class of noncoding small RNAs, called microRNAs (miRNAs), has emerged as important regulators in biological processes. The important role of miRNAs in inflammation and immune response is highlighted by studies in which deregulation of miRNAs was demonstrated to accompany diseases associated with excessive or uncontrolled inflammation. In this brief review, we summarize the roles of miRNAs that have been characterized in innate and adaptive immune responses. We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear effect on inflammation. (Arterioscler Thromb Vasc Biol. 2013;33:170-177.)
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