Journal
JOURNAL OF IMMUNOLOGY
Volume 170, Issue 11, Pages 5421-5428Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.170.11.5421
Keywords
-
Categories
Funding
- NCI NIH HHS [T32 CA72320] Funding Source: Medline
- NIAID NIH HHS [AI40614, AI39310] Funding Source: Medline
Ask authors/readers for more resources
Although costimulation plays an important role in activating naive T cells, its role in negative selection is controversial. By following thymocyte deletion induced by endogenous superantigens in mice lacking B7-1 and/or B7-2, we have identified a role for both B7-1 and B7-2 in negative selection. Studies using CD28-deficient and CD28/CTLA-4-double-deficient mice have revealed that either CD28 or another as yet undefined coreceptor can mediate these B7-dependent signals that promote negative selection. Finally, CTLA-4 delivers signals that inhibit selection, suggesting that CTLA-4 and CD28 have opposing functions in thymic development. Combined, the data demonstrate that B7-1/B7-2-dependent signals help shape the T cell repertoire.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available