Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 32, Issue 7, Pages 1552-1562Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.111.224915
Keywords
apoptosis; cell death; heart failure; myocardial infarction; necrosis
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Funding
- National Institutes of Health [5R01HL060665-14, 5P60DK020541-35, 5P30CA013330-39, 5T32AG023475-08]
- A.G. Leventis Foundation
- Dr Gerald and Myra Dorros Chair in Cardiovascular Disease
- Wilf Family
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The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic and pharmacological manipulations indicate that cell death is an important component in the pathogenesis of both diseases. Cells die primarily by apoptosis or necrosis, and autophagy has been associated with cell death. Apoptosis has long been recognized as a highly regulated process. Recent data indicate that a significant subset of necrotic deaths is also programmed. In the review, we discuss the molecular mechanisms that underlie these forms of cell death and their interconnections. The possibility is raised that small molecules aimed at inhibiting cell death may provide novel therapies for these common and lethal heart syndromes. (Arterioscler Thromb Vasc Biol. 2012;32:1552-1562)
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