Journal
GENES & DEVELOPMENT
Volume 17, Issue 11, Pages 1328-1333Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1077103
Keywords
telomere; ubiquitin; TRF1; tankyrase 1; PARP
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Funding
- NCI NIH HHS [R01 CA95099-01, R01 CA095099] Funding Source: Medline
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Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase I released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiquitination and degradation of TRF1 by the proteasome and that degradation is required to keep TRF1 off telomeres. Ubiquitination of TRF1 is regulated by its telomere-binding status; only the telomere-unbound form of TRF1 is ubiquitinated. Our findings suggest a novel mechanism of sequential posttranslational modification of TRF1 (ADP-ribosylation and ubiquitination) for regulating access of telomerase to telomeres.
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