Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 31, Issue 7, Pages 1485-1494Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.221101
Keywords
vascular biology; vascular muscle
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Funding
- NHLBI NIH HHS [R01 HL105114-01, R01 HL068878-11, R01 HL089544-04, R01 HL089544, R01 HL068878, R01 HL089544-05, R01 HL068878-10, R01 HL088391-04, R01 HL088391, R01 HL105114] Funding Source: Medline
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Development of in vitro models by which to study smooth muscle cell (SMC) differentiation has been hindered by some peculiarities intrinsic to these cells, namely their different embryological origins and their ability to undergo phenotypic modulation in cell culture. Although many in vitro models are available for studying SMC differentiation, careful consideration should be taken so that the model chosen fits the questions being posed. In this review, we summarize several well-established in vitro models available to study SMC differentiation from stem cells and outline novel mechanisms recently identified as underlying SMC differentiation programs. (Arterioscler Thromb Vasc Biol. 2011; 31:1485-1494.)
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