Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 31, Issue 5, Pages 969-979Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.110.207415
Keywords
atherosclerosis; immune system; vascular biology; cytokines; inflammation
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Funding
- Institut National de la Sante et de la Recherche Medicale
- Leducq Foundation
- Agence Nationale de la Recherche
- EU
- British Heart Foundation [RG/10/001/27643] Funding Source: researchfish
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Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses. Inflammation controls the development and the destabilization of arterial plaque. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis have provided evidence for a dual role of cytokines: proinflammatory and T helper-1-related cytokines promote the development and progression of the disease, whereas antiinflammatory and regulatory T cell-related cytokines exert clear antiatherogenic activities. This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosis. (Arterioscler Thromb Vasc Biol. 2011;31:969-979.)
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