Journal
ALCOHOL
Volume 30, Issue 2, Pages 145-150Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0741-8329(03)00129-0
Keywords
iron; cancer; liver cancer; hemochromatosis; HFE mutations; oxidative stress
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Mechanisms whereby iron may act in carcinogenesis are induction of oxidative stress, facilitation of tumor growth, and modification of the immune system. Results of clinical and epidemiologic studies demonstrate a strong association between iron excess (even at mild levels) and the development of cancer at any site, but they do not indicate whether this reflects a causal link or an indirect association through other factors (i.e., aging, alcohol consumption, and insulin resistance). Findings obtained from experimental work are not conclusive with respect to a direct carcinogenic role of iron, but they support a carcinogenic or co-carcinogenic role of iron in chemically induced carcinogenesis. (C) 2003 Elsevier Inc. All rights reserved.
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