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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Journal

CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 13, Issue 3, Pages 284-299

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(03)00081-2

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Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.

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