4.7 Article

Microbial Sensing by Toll Receptors A Historical Perspective

Journal

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 31, Issue 8, Pages 1734-1738

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.108.179523

Keywords

immune system; macrophages; receptors; viruses

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The family of Toll-like receptors plays an essential role in the induction of the immune response. These receptors sense the presence of microbial ligands and activate the nuclear factor-kappa B transcription factor. We review the key studies that led from the formulation of the concept of pattern recognition receptors to the characterization of Toll-like receptors, insisting on the important role played by the model organism Drosophila melanogaster and on the increasing evidence connecting these receptors to cardiovascular disease. (Arterioscler Thromb Vasc Biol. 2011; 31: 1734-1738.)

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