Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 31, Issue 9, Pages 2125-U530Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.111.227298
Keywords
aortic development; cholesterol; early development; myocardial function; young adults
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Funding
- British Heart Foundation [FS/06/024]
- Oxford Health Services Research Committee
- National Institute for Health Research Oxford Biomedical Research Centre
- Oxford British Heart Foundation Centre for Research Excellence
- Commonwealth Scholarship Commission
- MRC [G0700349] Funding Source: UKRI
- British Heart Foundation [FS/11/65/28865] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [V1244] Funding Source: researchfish
- Medical Research Council [G0700349] Funding Source: researchfish
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Objective-Intravenous lipid use is associated with an acute hyperlipidemia, but long-term consequences have not been studied. We investigated whether elevated lipids in humans during the critical period of preterm neonatal life have a long-term impact on aortic and myocardial function relevant to adult disease. Methods and Results-We followed up 102 subjects born prematurely and now aged 23 to 28 years. Eighteen received intravenous lipids as neonates and were matched to controls with equivalent perinatal characteristics. Global and regional aortic stiffness and left ventricular function were assessed by cardiovascular magnetic resonance. Those who received intravenous lipids had greater aortic stiffness in early adulthood (P = 0.0002), with greater stiffness in the abdominal aorta (P = 0.012). The relationship was graded according to the elevation in neonatal cholesterol induced by intravenous lipids (P < 0.0001) but not other metabolic parameters altered by the infusion. Peak systolic circumferential strain was also reduced in the lipid group (P = 0.006), which, again, was proportional to neonatal cholesterol level (P < 0.01). Conclusion-Aortic and myocardial function in young adulthood is associated with intralipid exposure during neonatal life for preterm infants, in a graded manner related to the rise in cholesterol. Circulating cholesterol during critical developmental periods may have long-term impacts on the human cardiovascular system. (Arterioscler Thromb Vasc Biol. 2011;31:2125-2135.)
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