Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 29, Issue 10, Pages 1419-1423Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/ATVBAHA.108.180497
Keywords
macrophage; inflammation; atherosclerosis
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Funding
- European Commission
- Fondazione Cariplo
- Ministero Istruzione Universita e Ricerca
- Ministero del Lavoro della Salute e delle Politiche Sociali
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Diversity and plasticity are hallmarks of mononuclear phagocytes, which are reflected in plaque formation and evolution. Different monocyte subsets, which differentially contribute to plaque infiltration and to atherosclerosis complications, have been identified. Similarly, depending on different environmental signals plaque-associated macrophages can express polarized pro- and antiatherogenic programs by influencing lipid metabolism, inflammatory responses, and plaque stability. Thus, a macrophage balance plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis. (Arterioscler Thromb Vasc Biol. 2009; 29: 1419-1423.)
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