Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 15, Issue 3, Pages 318-325Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(03)00049-8
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The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA-protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Cajal (coiled) bodies. Events of ribosome biogenesis are found solely-in the nucleolus, which is the final destination of small nucleolar RNAs after their traffic through Cajal bodies. However, nucleoli are just a stopping point in the intricate cellular traffic for small nuclear RNAs and other ribonucleoproteins.
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