4.7 Article Proceedings Paper

Vitamin D status and secondary hyperparathyroidism:: The importance of 25-hydroxyvitamin D cut-off levels

Journal

KIDNEY INTERNATIONAL
Volume 63, Issue -, Pages S44-S48

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1046/j.1523-1755.63.s85.11.x

Keywords

calcifediol; calcitriol; vitamin D deficiency; parathyroid hormone

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Background. Serum 25-hydroxyvitamin D is the best indicator of vitamin D status. However, some controversy remains regarding normal and abnormal values. This study's aim was to assess vitamin D status and prevalence of secondary hyperparathyroidism. Methods. A random sample of 326 subjects (164 women and 162 men, aged 68 9; range, 54 to 89) participating in the European Vertebral Osteoporosis Study (EVOS) was used to assess vitamin D status and secondary hyperparathyroidism. Only those subjects who had never received any kind of treatment for osteoporosis were included in this analysis. Results. Serum 25-hydroxyvitamin D levels were deficient (<10 ng/mL) in 27% of subjects, borderline (10-18 ng/mL) in 40% of subjects, and normal (>18 ng/mL) in 33% of subjects. The prevalence of secondary hyperparathyroidism (PTH >65 pg/mL) according to 25-hydroxyvitamin D levels was 33% (<10 ng/mL), 16% (10-18 ng/mL), and 12% (>18 ng/mL), respectively. There were no cases of secondary hyperparathyroidism with 25-hydroxyvitamin D levels >40 ng/mL. The independent predictors for PTH were 25-hydroxyvitamin D and serum creatinine in both sexes, but age was a predictor only in men. Conclusion. These remarkable findings demonstrate the importance of maintaining higher 25-hydroxyvitamin D levels to avoid stimulation of the parathyroid gland.

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