Journal
ARQUIVOS DE NEURO-PSIQUIATRIA
Volume 72, Issue 2, Pages 136-144Publisher
ASSOC ARQUIVOS NEURO- PSIQUIATRIA
DOI: 10.1590/0004-282X20130220
Keywords
high fat diet; pregnancy; lactation; somatic growth; reflex ontogeny; offspring
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2011/17574-4, 2011/17577-3, 2011/15329-2]
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The maternal exposure to high fat diet (HFD) during pregnancy and breastfeeding have been considered an important inducer of alterations in offspring normal programming, both in animals and humans, and may disturb brain development. In the present study we investigated the somatic and sensory-motor development of the offspring from rat dams fed a HFD, compared with dams fed a control diet, during pregnancy or lactation. Indicators of the body growth, physical maturation, and reflex ontogeny were evaluated. Offspring of dams fed a HFD showed reduced weight and body growth, delayed physical maturation, and delayed maturation of the physiological reflexes, such as vibrissa placing, auditory startle response, and free-fall righting. Our findings suggest that maternal HFD during pregnancy or lactation modifies somatic and neurological development of the offspring, possibly increasing the risk of neuroendocrine and neuropsychiatric disorders later in life.
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