Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 446, Issue 3, Pages 304-308Publisher
SPRINGER-VERLAG
DOI: 10.1007/s00424-003-1045-8
Keywords
vitamin D; hypercalciuria; oestrogen; ECaC1; ECaC2; calcium transport
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The epithelial calcium channels TRPV5 and TRPV6 have been studied extensively in the epithelial tissues controlling Ca2+ homeostasis and exhibit a range of distinctive properties that distinguish them from other transient receptor potential (TRP) channels. These two novel members of the superfamily of TRP channels were cloned from vitamin D-responsive epithelia: kidney, small intestine and placenta, and identified subsequently in tissues like pancreas, bone and prostate. This review addresses the unique properties of these highly Ca2+- selective channels and highlights their implications for the process of transepithelial. Ca2+ transport.
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