Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 28, Issue 6, Pages 313-320Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0968-0004(03)00112-9
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Integrins are one of the major families of cell-adhesion receptors. In the past year, the first structure of an integrin has been published, ligand-binding pockets have been defined, and mechanisms of receptor priming and activation elucidated. Like all major advances, however, these studies have raised more questions than they have answered about issues such as the mechanisms underlying ligand-binding specificity and long-range conformational regulation.
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