Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 13, Issue 3, Pages 246-252Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(03)00054-6
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In the past few years, there has been a nascent convergence of scientific understanding of inherited human diseases with epigenetics. Identified epigenetic processes involved in human disease include covalent DNA modifications, covalent histone modifications, and histone relocation. Each of these processes influences chromatin structure and thereby regulates gene expression and DNA methylation, replication, recombination, and repair. The importance of these processes for nearly all aspects of normal growth and development is illustrated by the array of multi-system disorders and neoplasias caused by their dysregulation.
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