Journal
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
Volume 25, Issue 6, Pages 512-518Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0885-3924(03)00070-8
Keywords
anemia; cancer; chemotherapy; quality of life; erythropoietin
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The purpose of this study was to assess whether the administration of recombinant human erythropoietin (rHuEPO) would correct anemia and improve the quality of life (QOL) in cancer patients receiving chemotherapy. One hundred. twenty-two patients with hemoglobin less than or equal to 11.0 g/dl were randomized to receive rHuEPO 10,000 U three times weekly (n = 61) or no additional treatment (n = 61). Response was assessed by measuring changes in hemoglobin level and QOL. QOL was evaluated before each cycle of chemotherapy at baseline, Week 4, and Week 12 using two separate self-report questionnaires. The analyses indicated, that the rHuEPO-treated patients experienced significantly less fatigue (P < 0.05) than their control group counterparts, and reported significantly higher scores on energy level (P < 0.05), ability to perform, daily activities (P < 0.01), and overall QOL (P < 0.05). The overall change in hemoglobin level was significantly greater in the rHuEPO group than in the control group (1.7 g/dl versus 0.3 g/dl, P < 0.001). rHuEPO effectively corrects anemia and significantly improves QOL in patients with solid tumors receiving chemotherapy. (C) 2003 U.S. Cancer Pain Relief Committee.
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