Journal
NUTRITIONAL NEUROSCIENCE
Volume 6, Issue 3, Pages 153-162Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1028415031000111282
Keywords
APP/PS1 transgenic mice; signaling; cognitive behavior; blueberry supplementation
Categories
Ask authors/readers for more resources
Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP+PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available