Journal
MOLECULAR DIVERSITY
Volume 7, Issue 2-4, Pages 125-133Publisher
SPRINGER
DOI: 10.1023/B:MODI.0000006807.43408.d5
Keywords
cyanation; dechlorination; Heck reaction; 2(1H)-pyrazinone; Sonogashira reaction; Stille reaction; Suzuki reaction
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Funding
- Fund for Scientific Research - Flanders (Belgium)
- Katholieke Universiteit Leuven
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The 2(1H)-pyrazinones have been demonstrated to be versatile building blocks for the synthesis of biologically active compounds. Here, an efficient method is described for the decoration of these interesting scaffolds. Microwave-assisted palladium catalyzed reactions allow the easy introduction of different substituents at the C3- and even at the rather unreactive C5-position of the pyrazinones. Stille, Suzuki, Heck, Sonogashira reactions, in addition to reductive dechlorinations, and cyanation reactions are investigated.
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