Journal
ANNALS OF NEUROLOGY
Volume 53, Issue 6, Pages 804-807Publisher
WILEY
DOI: 10.1002/ana.10597
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We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial AILS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.
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