Journal
DEVELOPMENT
Volume 130, Issue 11, Pages 2291-2301Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.00447
Keywords
Erbb2; Nrg1; muscle spindle; synapse; neuromuscular junction; mouse
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Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we have inactivated the Erbb2 gene in developing muscle fibers by Cre/Lox-mediated gene ablation. Neuromuscular synapses form in the mutant mice, but the synapses are less efficient and contain reduced levels of acetylcholine receptors. Surprisingly, the mutant mice also show proprioceptive defects caused by abnormal 2291 muscle spindle development. Sensory la afferent neurons establish initial contact with Erbb2-deficient myotubes. However, functional spindles never develop. Taken together, our data suggest that Erbb2 signaling regulates the formation of both neuromuscular synapses and muscle spindles.
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