Journal
JOURNAL OF NATURAL PRODUCTS
Volume 66, Issue 6, Pages 863-864Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np0204444
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Three new cytotoxic 3,6-disubstituted indoles (1-3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was separated from a Mexican marine invertebrate, and their structures established by analysis of NMR and mass spectral data. GI(50) values for I and 2 in cytotoxic bioassays against a panel of 14 different tumor cell lines were estimated at micromolar range, while compound 3 showed no activity in the same assays.
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