Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 34, Issue 11, Pages 1399-1404Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(03)00111-4
Keywords
nitroxyl; Angeli's salt; superoxide dismutase; glutathione; nitrite; free radicals
Funding
- NIDDK NIH HHS [1R01 DK 59868] Funding Source: Medline
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The classical view of the aerobic decomposition of Angeli's salt is that it releases NO2- + NO-/HNO the latter then reacting with O-2 to yield ONOO-. An alternative that has recently been proposed envisions electron transfer to O-2 followed by decomposition to NO2- + NO. The classical view is now strongly supported by the observation that the rates of decomposition of Angeli's salt under 20% O-2 or 100% O-2 were equal. Moreover, NO2-, which inhibits this decomposition by favoring the back reaction, was more effective in the absence of agents that scavenge NO-/HNO. It is thus clear that Angeli's salt is a useful source of NO-/HNO for use in defined aqueous systems. The measurements made in the course of this work allowed approximation of the rate constants for the reactions of NO-/HNO with NO2-, O-2, glutathione, or Cu, Zn superoxide dismutase. The likelihood of the formation of NO-/HNO in vivo is also discussed. (C) 2003 Elsevier Inc.
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