Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 35, Issue 6, Pages 826-837Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S1357-2725(02)00307-2
Keywords
diet; adipocyte; blood pressure; vasoconstriction; angiotensin converting enzyme; kidney; vascular; leptin; resistin; adiponectin
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The renin-angiotensin system (RAS) and the endothelin system have been implicated in the pathogenesis of human cardiovascular and renal diseases, and inhibition of the RAS markedly improves morbidity and survival. Obesity in humans is associated with an increased risk for the development of hypertension, atherosclerosis and focal-segmental glomerulosclerosis, however the exact mechanisms underlying these pathologies in obese individuals are not known. This article discusses the clinical importance of obesity and the current evidence for local activation of the renin-angiotensin system and its interactions with the endothelin system in obesity and the cardiovascular pathologies associated with it. (C) 2003 Elsevier Science Ltd. All rights reserved.
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