Journal
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
Volume 73, Issue 4, Pages 338-342Publisher
CONSEL BRASIL OFTALMOLOGIA
DOI: 10.1590/S0004-27492010000400007
Keywords
Diabetic retinopathy/drug therapy; Injections; Vitreous body; Intraocular pressure; Macular edema/drug therapy; Retina/drug effects; Ketorolac tromethanine/administration & dosage; Laser coagulation; Visual acuity
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Purpose: To evaluate the effect of a single dose of intravitreous injection of ketorolac tromethamine (500 mu g/0.1 ml) in patients with diabetic macular edema refractory to retinal photocoagulation. Methods: Prospective study. Twenty patients with bilateral diabetic macular edema and ETDRS best-corrected visual acuity between 20/50 and 20/200 were selected. Patients who had other ocular diseases or previous eye surgery were excluded. Preservative-free ketorolac tromethamine was injected intravitreally (500 mu g in 0.1 ml) in 20 eyes; fellow eyes served as controls. Ophthalmic examinations included ETDRS best-corrected visual acuity, measurement of intraocular pressure and optical coherence tomography. The examinations were performed preoperatively, 1 week and 1 month postoperatively. Results: A statistically significant increase in visual acuity over time in the treated eye compared with the fellow eye was noted (p=0.039). There were no statistically significant differences in the assessment of intraocular pressure (p=0.99), foveal thickness (p=0.86) and macular volume (p=0.23) during the period. Conclusion: Patients with diabetic macular edema refractory to photocoagulation showed improvement in visual acuity over a one month period with a statistically significant difference when compared with the control eye. There were no statistically significant differences in intraocular pressure, foveolar thickness and macular volume between the treated and control eyes.
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