Journal
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA
Volume 71, Issue 6, Pages 47-54Publisher
CONSEL BRASIL OFTALMOLOGIA
DOI: 10.1590/S0004-27492008000700010
Keywords
Corneal diseases/therapy; Conjunctival diseases/therapy; Lacrimal apparatus/abnormalities; Serum; Ophthalmic solutions/therapeutic use
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Autologous serum has been used to treat dry eye syndrome for many years. It contains several growth factors, vitamins, fibronectin and other components that have been considered important for corneal and conjunctival integrity. Serum eye drops are usually prepared as an unpreserved blood solution. The serum is by nature well tolerated and its biochemical properties are somewhat similar to natural tears. Autologous serum eye drops have been reported to be effective for the treatment of severe dry eye-related ocular surface disorders (Sjogren's syndrome), and also other entities such as superior limbic keratoconjunctivitis, graft-versus-host disease, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, recurrent or persistent corneal erosions, neurotrophic keratopathy, Mooren's ulcer, aniridic keratopathy, filtering blebs after trabeculectomy, and post-keratorefractive surgery. The purpose of this study is to review the recently published literature on ocular surface diseases treated with human autologous serum eye drops.
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