Journal
GENE EXPRESSION PATTERNS
Volume 3, Issue 3, Pages 337-339Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-133X(03)00030-9
Keywords
zebrafish; development; hair cell; statoacoustic ganglion; cell adhesion molecule
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Funding
- NEI NIH HHS [EY04318, EY11365, EY13879] Funding Source: Medline
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Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11 mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells. (C) 2003 Elsevier Science B.V. All rights reserved.
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