Journal
DIABETES
Volume 52, Issue 6, Pages 1579-1582Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diabetes.52.6.1579
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Funding
- NIAID NIH HHS [AI 29049] Funding Source: Medline
- NIDDK NIH HHS [DK 46626] Funding Source: Medline
- NIGMS NIH HHS [R01 GM062628, 5R01 GM 062628, 5R01 GM 053275] Funding Source: Medline
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Type 1 diabetes is an autoimmune disease with a Th1 phenotype in which insulin-producing beta-cells in the pancreas are destroyed. The T-cell-specific transcription factor TCF7 activates genes involved in immune regulation and is a candidate locus for genetic susceptibility to type 1 diabetes. A nonsynonymous single nucleotide polymorphism (SNP) (Pro to Thr) in the TCF7 gene, C883A, was examined in samples from 282 Caucasian multiplex typed diabetic families. HLA-DRB1 and -DQB1 genotypes were, previously determined for these samples, allowing data stratification based on HLA-associated risk. The transmission disequilibrium test showed significant overtransmission of the A allele from fathers (64.1%, P < .0.007) and nonsignificant overtransinission (57.4%, P < 0.06) of the A allele to patients. who do not carry the highest-risk HLA-DR3/DR4 genotype. Elliptical sib pair analysis showed significant associations of the A allele with type l diabetes in paternal transmissions (P < 0.03), transmissions to male children (P < 0.04), and in the non-DR3/DR4 group (P < 0.04). These data also suggest that TCF7 C883A may affect age of disease onset. Analysis of genotype data from surrounding SNPs suggests that this TCF7 polymorphism may itself represent a risk factor for type 1 diabetes. Diabetes 52:1579-1582, 2003.
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