Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 67, Issue 6, Pages 1410-+Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.67.1410
Keywords
spermidine; Sinularia; marine natural products; cytotoxicity; apoptosis
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Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N', N, N-trimethylspermidines that are acylated by a methyl-branched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC50 value of 17 ng/ml and the induction of apoptotic phenomena.
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