Journal
NATURE REVIEWS CANCER
Volume 3, Issue 6, Pages 444-451Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1096
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The outer covering of the skin-the epidermis-is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?.
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