Journal
CURRENT MEDICINAL CHEMISTRY
Volume 10, Issue 12, Pages 1077-1084Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867033457584
Keywords
iron chelation; 8-hydroxyquinoline; O-TRENSOX; thermodynamic and kinetics of complexation; lipopbilic/hydrophilic chelators; iron nutrition; iron mobilization
Ask authors/readers for more resources
The interest in synthetic siderophore mimics includes therapeutic applications (iron chelation therapy), the design of more effective agents to deliver Fe to plants and the development of new chemical tools for studies of iron metabolism and for a better understanding of iron assimilation processes in living systems. The 8-hydroxyquinoline bidentate chelate moiety offers an alternative to the usual hydroxamic acid, catechol and/or alpha-hydroxycarboxylic acid metal-binding groups encountered in natural siderophores. The promising results obtained by the tris hydroxyquinoline-based ligand O-TRENSOX are summarized. O-TRENSOX exhibits a high and selective affinity for Fe(Ill) complexation. Its efficiency in delivering Fe to plants as well as its efficiency for iron mobilization, cellular protection and anti proliferative effects have been evidenced. Other chelators of the O-TRENSOX family (mixed catechol / 8-hydroxyquinoline ligands, lipophilic ligands) are also described. Some results question whether the use of partition coefficients is pertinent to foresee the activity of iron chelators. The development of probes (fluorescent, radioactive, spin labelled) based on the O-TRENSOX backbone is in progress. 8-hydroxyquinoline iron chelators seem to have a promising future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available