Journal
CNS SPECTRUMS
Volume 8, Issue 6, Pages 446-449Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1092852900018757
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Migraine pain-relay centers, including the trigeminal ganglion, trigeminal nucleas caudalis, and thalamus, contain glutamate-positive neurons, and glutamate activates the trigeminal nucleus caudalis. Glutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Glatamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. These preclinical and clinical observations argue for a strong link between migraine and the glutamatergic system, a link that is important to further characterize in an effort to better understand migraine mechanisms and deliver effective therapies.
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